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Xlinked Dominant Inheritance Psychology Wiki Fandom Nephrogenic Diabetes Insipidus Wikipedia When nephrogenic diabetes insipidus results from mutations in the avpr2 gene, the condition has an x-linked recessive pattern of inheritance. the avpr2 gene is located on the x chromosome, which is one of the two sex chromosomes. in males (who have only one x chromosome), one altered copy of diabetes insipidus x linked recessive the gene in each cell is sufficient to cause the. Nephrogenic diabetes insipidus is a form of diabetes insipidus primarily due to pathology of the kidney. this is in contrast to central/neurogenic diabetes insipidus, which is caused by insufficient levels of antidiuretic hormone (adh, that is, arginine vasopressin or avp). X-linked ndi is generally a rare disease in which the affected male patients do not concentrate their diabetes insipidus x linked recessive urine after administration of avp. because this form is a rare, recessive x-linked disease, females ar...